Science
Five active principles, ten products
Reglory is built on five mechanisms. Each answers a different question about ageing skin, each appears in more than one presentation, and each is documented in the manufacturer's own catalogues — with concentrations, injection layers and intervals. What follows is that documentation, organised, without addition.
Polynucleotides
Purified biomolecules that act as biostimulators. In four products.
Exosomes
Vesicles with a membrane identical to the one they cross. In three.
NAD⁺ and NMN
The coenzyme that runs cellular energy and DNA repair.
Hyaluronic acid
Two molecular weights, crosslinked and non-crosslinked. In five.
rh-Collagen
Human-identical collagen types I and III, grown by fermentation.
01 — Polynucleotides
Purified biomolecules
Polynucleotides are purified biomolecules injected into the skin to enhance its regenerative ability and maintain a youthful look. Known as biostimulators or biorevitalisers, they promote skin renewal, improve texture and strengthen the barrier.
Reglory uses PN rather than PDRN. While PDRN — sodium DNA — primarily supports healing and tissue repair, PN works at a deeper level: stimulating collagen production, improving elasticity and enhancing cell renewal. PN also has a higher molecular weight and better biocompatibility, which the manufacturer links to longer-lasting results and improved skin density.
In: PN+ · Eyes Black · Eyes · RH Collagen
- Physicochemical
- Hydration effect · scaffolding effect · long-lasting effect
- Biological
- Epidermis and dermis regeneration · collagen and non-collagen protein secretion · extracellular matrix restoration
How much PN, where
| Product | Polynucleotide | Also contains |
|---|---|---|
| PN+ | 5 mg / 2.5 ml | Sodium hyaluronate 50 mg, niacinamide, glutathione |
| Eyes Black | 20 mg / 2 ml — 1% | Nothing else. Single active |
| Eyes | 2 mg / ml | Niacinamide 3 mg/ml, botulinum polypeptide |
| RH Collagen | 5 mg / 2.5 ml | rh-Collagen I and III, HA 50 mg |
02 — Exosomes
Vesicles that cross tissue
Exosomes, created through a process of isolation and purification from stem cells, have a lipid membrane identical to that of cell membranes, enabling them to traverse any tissue within the body.
Reglory works with two origins, and the manufacturer separates them explicitly: animal-derived exosomes from human adipose stem cells, and plant exosomes extracted directly from Centella Asiatica. Both arrive as a 200 mg lyophilised powder with a 6 ml activating diluent, reconstituted immediately before the procedure.
In: EXO+ · EXO+ PLANT · EXO+ HAIR
| EXO+ | EXO+ PLANT | EXO+ HAIR | |
|---|---|---|---|
| Origin | Human adipose-derived stem cell conditioned media | Centella Asiatica leaf vesicles — plant | Human adipose-derived stem cell conditioned media |
| Concentration | 95% · 950,000 ppm | Not declared as a percentage | 95% · 950,000 ppm |
| Also contains | Niacinamide, adenosine, sodium hyaluronate, sodium PCA, betaine | Hydrolysed collagen, niacinamide, adenosine, sodium hyaluronate, sodium PCA, betaine | Caffeine, glutamic acid, sodium hyaluronate, sodium PCA, betaine |
| Area | Face, neck, back of hands | Face, neck, back of hands, scalp | Scalp only |
| Interval | 4 treatments, 7–15 days apart | 4 treatments, 7–15 days apart | Per protocol |
Why the plant line exists, in the manufacturer's words: plant-derived exosomes contain no genetic material or proteins, so the risk of triggering an immune response is low; they are free of cholesterol, which minimises irritation; and they carry no zoonotic pathogens.
03 — NAD⁺ and NMN
Energy before structure
Derived from vitamin B3, NAD⁺ levels drop by up to 50% by the fifties compared with the twenties. NMN is a direct precursor: small enough for high cellular absorption, and rapidly converted into NAD⁺.
Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) are NAD⁺-dependent enzymes with critical roles in DNA repair, genomic stability and cellular survival. As NAD⁺ activity increases, DNA repair efficiency is enhanced — which is why the manufacturer positions this formulation upstream of hydration and of regeneration rather than alongside them.
In: NAD⁺ NMN
Three mechanisms, compared
| Hyaluronic acid | Polynucleotide | NAD⁺ | |
|---|---|---|---|
| Primary target | Hydration, structural support | Tissue regeneration | Cellular metabolism, genetic regulation |
| Mechanism | Moisture barrier reinforcement, volume filling | Cell proliferation, TGF-β activation | Energy production, sirtuin activation, DNA repair |
| Ageing addressed | Extrinsic — dehydration, volume loss | Intrinsic and extrinsic — damage repair | Intrinsic — gene regulation |
| Onset | Immediate | Gradual and steady | Gradual, cellular level |
The manufacturer's own comparison, reproduced from the NAD⁺ NMN catalogue.
04 — Hyaluronic acid
Two molecular weights
High molecular weight HA forms a moisture barrier, retains hydration, boosts elasticity and keeps the skin plump. Low molecular weight HA hydrates the inner layers, promotes regeneration, improves tone and smooths texture.
HL 40+ carries both at 40 mg per 2.5 ml, non-crosslinked, produced with a proprietary high-concentration technology and formulated to address the limitations of traditional monophasic and biphasic products, which the manufacturer describes as lacking elasticity and viscosity. Lip uses crosslinked HA at 2.4% with anthocyanins — a different job entirely, and the only crosslinked presentation in the range.
In: HL 40+ · Lip · and as sodium hyaluronate in PN+, NAD⁺ NMN, RH Collagen and the three EXO+ presentations
05 — Recombinant human collagen
Human-identical, animal-free
Recombinant collagen is human-identical collagen bioengineered through a yeast fermentation process. It offers 100% sequence identity with human collagen and reaches up to 95% purity, with no chemical residues and low allergy risk.
Type I is the most abundant collagen in the skin: it supports structure and firmness and fills deep wrinkles. Type III is found in young and healing skin: it boosts flexibility and softness and accelerates tissue repair. RH Collagen carries both, at 7.5 mg each, with high molecular weight HA, polynucleotide and a four-peptide complex.
In: RH Collagen
| Recombinant humanized collagen | Animal collagen | |
|---|---|---|
| Homology | 100% identical to the human collagen sequence | Different amino acid sequence |
| Biological activity | High, correct triple-helix structure | Reduced — structural damage during extraction |
| Stability | Highly stable via fermentation | Inconsistent — natural raw material variability |
| Immunogenicity | Not applicable — animal-free | May trigger immune reactions |
| Pathogenicity | Not applicable | Risk of viral contamination |
| Crosslinking agent | Not applicable | Often required |
| Religious or cultural | Not applicable | May conflict — e.g. porcine origin |
The supporting cast
What sits beside the active
No Reglory presentation is a single molecule in water. These are the secondary actives that recur across the range, and what the manufacturer says each one does.
Niacinamide
Skin tone improvement and whitening effect, sebum and pore reduction, blemish improvement, acne scar reduction, barrier enhancement, dryness relief.
EXO+, EXO+ PLANT, PN+, EyesGlutathione
Brightens skin and fades dark spots, powerful antioxidant protection, evens out tone and detoxifies.
PN+, NAD⁺ NMNSuccinic acid
Strong antioxidant, boosts skin metabolism, improves oxygen supply, promotes collagen production, brightens tone and fades pigmentation.
HL 40+ — 40 mg / 2.5 mlCopper tripeptide-1 (GHK-Cu)
Stimulates collagen and elastin growth, supports repair, smooths fine lines, boosts firmness.
HL 40+Anthocyanins
Natural vitality and antioxidant care, in the only crosslinked presentation of the range.
Lip — 1 mg / ml, 0.1%Caffeine
The single difference between the face and the scalp exosome formula, alongside glutamic acid.
EXO+ HAIRSodium PCA and betaine
The humectant pair behind every EXO+ presentation, holding water in the treated layer.
All three EXO+ productsPeptide complex
Galloyl tripeptide-35, nicotinoyl tripeptide-1, nicotinoyl octapeptide-9 and acetyl hexapeptide-8 — firmness, texture, barrier, radiance.
RH CollagenAcross the range
Layer, depth, needle, interval
Every catalogue publishes its own protocol. Side by side, they show how differently these ten formulations are meant to be placed in the skin.
| Product | Indication | Injection depth | Needle | Interval |
|---|---|---|---|---|
| EXO+ | — | — | — | 4 treatments, at least 7–15 days apart |
| EXO+ PLANT | — | — | — | 4 treatments, 7–15 days apart |
| EXO+ HAIR | — | — | — | — |
| PN+ | Upper to mid dermis | Approximately 1.0–2.0 mm, directly beneath the epidermis | 31G or 32G, 4 mm or 6 mm; thin-wall recommended | 3–5 sessions, 2–3 weeks apart; booster every 3 months |
| EYES BLACK | Upper dermis | Periorbital area approx. 0.5 mm; other facial areas 0.8–1.15 mm | 30–32G. Needles are not included | 2–3 sessions per month, 1 week apart |
| EYES | Superficial layer or epidermis / dermis | — | 32G × 4 mm. Needles are not included | 3 sessions, 4 weeks apart; repeat twice a year |
| NAD⁺ NMN | Superficial dermis | Approximately 0.8–1.3 mm, superficial to mid dermis | 30–34G. Cannula use is not recommended at this depth | At least 4 sessions, 2–4 weeks apart |
| RH COLLAGEN | Superficial to mid dermis | 1.0–2.0 mm, into areas of high fibroblast density | 30–34G, 4–13 mm; 32–34G preferred for reduced pain | 3 sessions 2–3 weeks apart, then 1 session every 3–6 months |
| HL 40+ | Epidermis / dermis | — | 29G. Needles are not included | 2 sessions, 1 month apart |
| LIP | — | — | — | — |
Needles are not included with any presentation. Treatment protocols may vary depending on the practitioner's clinical experience and treatment environment; these are the manufacturer's guidelines.
Who develops it
EVIE Korea, Republic of Korea
Reglory is the professional injectable line of EVIE Korea — EVIE Pharm — a Korean cosmeceutical and medical device manufacturer that also develops the Medisco and Stayve ranges and supplies them internationally.
Every Reglory catalogue carries the same three lines: innovative medical devices by EVIE Korea, precision care, proven technology, and Korean professional cosmeceutical brand. Each product is documented in its own catalogue — composition with declared concentrations, indication layer, injection depth, volume per point, needle gauge, treatment interval, pre- and post-treatment guidance, side effects and contraindications. Those catalogues are the only source for this website.
Innovative medical devices
by EVIE Korea
Precision care.
Proven technology.
Korean professional
cosmeceutical brand
A note on evidence
What this page does not claim
Everything above is drawn from the product catalogues issued by EVIE Korea. Those catalogues describe compositions, mechanisms and protocols. They do not publish clinical trials, efficacy percentages, patient numbers or certification marks, and nothing of that kind is claimed here.
Where a catalogue states a figure — 95% conditioned media, 950,000 ppm, 100% sequence identity, a 50% decline in NAD⁺ by the fifties — it is reproduced as the manufacturer states it, and attributed to them. Nothing on this site is medical advice, and nothing replaces the practitioner's own judgement.